The WCHS was chartered by the State of Ohio on February 27, 1973. The first board of directors started a serious fundraising campaign to build an animal shelter to house stray and abandoned dogs and cats in Wayne County.

In 1976, the board of directors was approached by the mayor of Wooster to contract the Humane Society for animal control within the city. An agreement was signed and the city of Wooster arranged to lease property to the humane society for the purpose of building an animal shelter. The shelter was later built for $40,000.00.

In March of 1980, the Wayne County Commissioners contracted with the Humane Society to house and care for all dogs picked up by the Wayne County Dog Warden's Office. After 35 years, this contract was terminated by the Wayne County Commissioners. The County assumed Dog Pound duties September 1, 2015.

In 1995, the WCHS animal shelter was over-crowded and desperately needed to grow. Another crucial fundraising campaign resulted in the renovation of the old shelter and a new building. The animals were moved into the new building on September 1, 1996. The renovations and new building were paid for by private donations, totaling over $600,000.00. The shelter remains today and is staffed by full and part-time employees, as well as numerous irreplaceable volunteers. All of the efforts of the past and present staff, volunteers, and board members are done to benefit homeless animals in Wayne County and to secure the mission of the WCHS.